Testosterone Enanthate (250mg/ml)

28.00

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Description

  • Active ingredient: Testosterone Enanthate
  • Type: Anabolic steroid (Testosterone derivative)
  • Form: Injection

Carrier oil: Grape seed oil

Description:

Testosterone is a primary sex hormone found in humans, playing a crucial role in the development of male reproductive tissues such as the testes and prostate. It also contributes to the development of secondary sexual characteristics in both men and women, including increased muscle and bone mass and body hair. Testosterone is vital for overall health and well-being and helps prevent conditions like osteoporosis. Insufficient testosterone levels in men can lead to abnormalities, such as frailty and bone loss. Testosterone is renowned for its anabolic properties, promoting muscle mass, protein synthesis, glycogen supply to muscles, and more. It governs numerous processes in the body and is a commonly used hormone for both age-related hypogonadism in elderly individuals and as a foundation for athletes during steroid cycles.

Mechanism of action:

Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone, a biologically active androgen formed through the conversion of testosterone by the enzyme 5α-reductase. Dihydrotestosterone exhibits approximately five times greater affinity for androgen receptors. When these hormones interact with receptors, they cause structural changes that trigger signaling to the cell nucleus. Androgenic effects are realized through alterations in the activity of specific DNA genes. Testosterone can also undergo aromatization, converting to estrogen. Estrogens, rather than testosterone itself, predominantly activate feedback through the hypothalamus-pituitary-testes axis and suppress endogenous testosterone secretion in the presence of exogenous testosterone drugs.

Medical Use:

Testosterone is included in the World Health Organization’s list of essential medicines, emphasizing its significance in a basic health system. While commonly associated with its anabolic effects for muscle growth, testosterone is also a vital hormonal drug. It is used in the treatment of gender dysphoria, male hypogonadism, and certain types of breast cancer. Hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) is necessary for maintaining health and quality of life in individuals experiencing age-related testosterone decline.

Testosterone plays a role in various cognitive functions, including mood, spatial ability, attention, and memory. Preliminary evidence suggests that low testosterone levels may be a risk factor for cognitive decline and Alzheimer’s disease.

In addition to its effects on male health, testosterone is crucial for the well-being of both sexes and the prevention of osteoporosis. Insufficient testosterone levels in men can result in frailty and bone loss, while testosterone treatment is beneficial for men with age-related low testosterone levels experiencing sexual dysfunction.

Testosterone for seniors:

Men over 35 who report diminished well-being are often advised to test their testosterone levels. If levels fall below 12 nmol/L, hormone replacement therapy is typically recommended. This decision offers several positive aspects. Body composition improves, with increased muscle and decreased fat mass. Sexual function experiences revitalization, and a certain rejuvenating effect is observed. In general, the body rebounds from the negative effects associated with androgen deficiency.

Regular monitoring of lipid profiles, general blood parameters, estradiol levels, and prolactin levels is essential. Additionally, as natural gonadotropin production approaches zero during hormone replacement therapy, special therapy with the use of gonadotropins becomes necessary for individuals desiring offspring.

It is crucial to consult with a healthcare professional to determine the appropriate dosage for testosterone therapy. Dosage depends on individual factors such as normal testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and aromatization process.

For reference, approximate dosages for replacement therapy are considerably lower than those used by athletes, ranging from 50-200 mg per week.

Testosterone in sports:

The primary advantage of testosterone in sports is its ability to increase muscle mass and strength. Alongside its anabolic effects, testosterone exhibits a potent androgenic effect. Androgens enter cells and interact with androgen receptor (AR) proteins. This interaction triggers a shape change in the AR protein, activating it. The activated AR protein enters the nucleus and binds to DNA, influencing gene expression.

Rapid weight gain associated with testosterone use is often due to significant water retention, sodium retention, and estrogenic effects. Testosterone can be effective in alleviating joint problems, pain, and stiffness in the shoulders and knees. However, compounds like nandrolone and growth hormone are often preferred for this purpose. Testosterone stimulates regeneration processes in the body, improves overall tone and exercise drive, and helps prevent overtraining. It also enhances oxygen capacity in the blood and nitric oxide production, resulting in a satisfying pump during training sessions.

The recommended dosage in sports ranges from 250-500 mg per week, with dosage adjustments based on the athlete’s body weight. Testosterone cycles typically last 8-10 weeks, followed by a post-cycle therapy period of 2-3 weeks. Prolonged testosterone use is not uncommon among athletes. In high-level professional athletes, the maximum dosage is typically 2000 mg per week, as further dosage increases yield no additional benefits and only increase the risk of side effects.

To avoid the development of estrogenic side effects resulting from the aromatization process, regular testing and the use of aromatase inhibitors are highly recommended. Monitoring estradiol levels before and during aromatase inhibitor use helps assess effectiveness and determine the appropriate dosage. However, it is strongly advised to rely on professionals for dosage selection.

Dosages:

  • Beginner: 250 mg per week
  • Average dosage: 300-750 mg per week
  • High dosage: 750+ mg per week

Effects:

  • Increased muscle mass
  • Development of male genital organs and secondary sexual characteristics (e.g., deepened voice, male facial features, male-pattern hair growth)
  • Facilitates spermatogenesis and male behavior (e.g., sexual drive, aggressiveness, resoluteness)
  • Burning of fat
  • Increased strength
  • Enhanced libido
  • Reduced blood cholesterol levels
  • Decreased risk of heart ischemia and coronary heart disease
  • Stimulation of erythropoiesis and distribution of subcutaneous fatty tissue in a male-like pattern
  • Influences nitrogen and phosphorus metabolism

Side effects:

  • Increased blood pressure
  • Heightened sexual behavior
  • Hemoconcentration (blood clotting)
  • Potential for blood clots in arterial and venous vessels
  • Water retention (edema)
  • Masculinization effects
  • Aggression, agitation, irritability
  • Alopecia (scalp baldness)
  • Acne
  • Insomnia (rare)

Profile:

  • Half-life: 4-5 days
  • Injection frequency: 4-7 days

Pharmaceutical form:

  • Oily solution for intramuscular injection

Contraindications:

  • Pregnancy
  • Known or suspected prostate or breast carcinoma
  • Breastfeeding
  • Hypersensitivity to the active substance or any of the excipients

Storage:

  • Do not use after the expiration date
  • Store between 8ºC and 30ºC
  • Avoid freezing
  • Protect from light